Plaque Vision
Plaque Vision
histopath findings mcq?
A 38-year-old women has persistence right arm weakness, which she has always attributed to too much aerobic activity in her early thirties. She has gradual rapid onset of blurry vision. Radiographic imaging demonstrate multiple demyelinated plaques. Appropriate clinical tests verify the diagnosis. Biopsy of the plaque in the central nervous system region responsible for the arm weakness would most likely indicate which of the following histopathologic findings?
A. Complete loss of axons
B. Gliosis
C. Histiocytic infiltration
D. Lymphocytic infiltration
E. Myelin breakdown
note that i have not yet taken histo and i am doing some step 1 prep, so any help would be appreciated.
The disease is likely Multiple sclerosis and the hard demyelinated plaques that form are going to have lots of lymphocyte infiltrate in and around them. Therefore I could see either D or E as being the answer... if I had to decide though, I might think they want the tricky answer of lymphocytic infiltratration, since MS is an autoimmune disease.
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